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 Increase Your Awareness With Basic Facts About Invega (Paliperidone)

BY NIKKI AND ANNE HEART ♥  May 6, 2025

*Picture displayed is a general picture and should not be used as a pill identifier.

The following highlights the basic facts. More information can be obtained through the sites listed below as well as many other informational sites regarding ingredients in medications and supplements. Information facts can change. Make sure you have all up-to-date information.

The following information pertains to Paliperidone tablet form. Information regarding Paliperidone extended-release injections may be different.
Basic facts about Invega (Paliperidone):
 
  • Paliperidone is in a class of medications called atypical antipsychotics.
  • Paliperidone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions).
  • Oral tablet
Brand names for Paliperidone:
  • Invega®
Brand names for Paliperidone extended-release injections
  • Erzofri®
  • Invega Hafyera®
  • Invega Sustenna®
  • Invega Trinza® 
Invega® is FDA approved:
  • First FDA approval December 21, 2006 for Schizophrenia
  • April 27, 2007, for Long term maintenance of Schizophrenia
  • August 6, 2009, for the treatment of Schizoaffective Disorder
  • April 11, 2011, for the treatment of Schizophrenia in adolescence

Important Safety Information

Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as paliperidone have an increased risk of death during treatment. Older adults with dementia may also have a greater chance of having a stroke or ministroke during treatment.

Paliperidone is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication, if you, a family member, or someone you care for has dementia and is taking paliperidone. For more information, visit the FDA website: https://www.fda.gov/Drugs

Side effects that can be caused by Invega (Paliperidone)

  • dizziness, feeling unsteady, or having trouble keeping your balance
  • extreme tiredness
  • weakness
  • headache
  • dry mouth
  • increased saliva
  • weight gain
  • stomach pain

Some side effects of  can be serious. If you experience Invega (Paliperidone) any of the following symptoms, call your doctor immediately.

  • fever
  • muscle pain or stiffness
  • falling
  • confusion
  • fast, pounding, or irregular heartbeat
  • sweating
  • unusual movements of your face or body that you cannot control
  • slow or stiff movements
  • restlessness
  • painful erection of the penis that lasts for hours

Important Warning

Invega (Palperidone) may cause:
  • Heart Rhythm Changes. Paliperidone may cause a rare, dangerous heart rhythm problem 
  • Metabolism Changes. Paliperidone can cause high blood sugar levels or diabetes, high cholesterol levels, and weight gain.
  • Uncontrolled Movements. Paliperidone can cause some people to have movements that they cannot control called tardive dyskinesia
  • Low Blood Pressure Upon Standing and Falls
  • Blood Disorders.
  • Neuroleptic Malignant Syndrome

Sourced used.

  1. Medlineplus.gov, Paliperidone,  accessed April 24, 2025 
  2. Nami.org, Invega (Paliperidone), accessed April 24, 2025
  3. Invega, accessed April 24, 2025
  4. Goodrx.com, Invega, accessed April 24, 2925
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Note: All information in “Nikki’s Story and Mom’s Story” are based on detail journals covering seven years of Nikki’s life on prescription drugs.

Medical Disclaimer: We share informational resources that are intended to help you with your self-care plan. We are not professionals. We write based on personal experience and personal research.

Nothing on this Website is intended to be taken as medical advice. The information provided on the Website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.

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