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Increase Your Awareness With Basic Facts About Cobenfy (Xanomeline and Trospium Chloride)
BY NIKKI AND ANNE HEART ♥ April 29, 2025
*Picture displayed is a general picture and should not be used as a pill identifier.
The following highlights the basic facts. More information can be obtained through the sites listed below as well as many other informational sites regarding ingredients in medications and supplements. Information facts can change. Make sure you have all up-to-date information.
Basic facts about Cobenfy (Xanomeline and Trospium Chloride) include:
- Xanomeline and trospium is in a class of medications called muscarinic agonists.
- Xanomeline and trospium is used to treat schizophrenia.
Brand names for Xanomeline and Trospium Chloride:
- Cobenfy®
Cobenfy® is FDA approved:
- FDA approval date: September 26, 2024.
- For the treatment of schizophrenia in adults.
Important things to know:
- Swallow the capsules whole; do not open, split, chew, or crush them.
- Your doctor will probably/may start you on a low dose of xanomeline and trospium and gradually increase your dose.
- Xanomeline and trospium controls schizophrenia but does not cure it. Continue to take xanomeline and trospium even if you feel well. Do not stop taking xanomeline and trospium without talking to your doctor.
Important Safety Information
Do not take COBENFY if you have: |
- trouble emptying your bladder completely or at all (urinary retention problems)
- moderate or severe liver problems (impairment)
- gastric retention problems (your stomach empties slower than it should)
- an allergy to COBENFY, xanomeline, trospium chloride, or any of the ingredients in COBENFY
- an eye problem called untreated narrow-angle glaucoma (fluid build-up in your eye)
Side effects that can be caused by Xanomeline and Trospium Chloride:
- constipation
- stomach pain
- diarrhea
- feeling like heart is racing or beating fast
- dizziness
- dry mouth
- sleepiness
- high blood pressure
- vomiting
- blurry vision
Some side effects of Cobenfy® can be serious. If you experience Cobenfy (Xanomeline and Trospium Chloride) any of the following symptoms, call your doctor immediately.
- hesitant urinating, weak urine stream, feeling like bladder isn’t emptying all the way, or painful urination
- yellowing of skin or whites of eyes, dark urine, lower abdominal pain
- heartburn, bloating or belching; nausea and/or vomiting; upper abdominal pain
- constipation or diarrhea, feeling full early in eating a meal; bloating, cramping, or pain
- swelling of the face, throat, tongue, orlips
- rash, hives, itching, wheezing or difficulty breathing
- dizziness, confusion, sleepiness, hallucinations
Cobenfy® may cause:
- Problems with emptying your bladder (urinary retention)
- Increased chance of side effects in people with liver problems (impairment)
- Blockage in your bile ducts in people with bile duct and gallbladder problems (biliary disease)
- Slow emptying of your stomach (decreased gastrointestinal motility)
- Serious allergic reactions (angioedema)
- An eye problem called narrow-angle glaucoma
- Higher heart rate (pulse) than usual
- Increased chance of side effects in people with kidney problems
Sourced used.
- Medlineplus.gov, Xanomeline and trospium chloride, accessed April 22, 2025
- Cobenfy, accessed April 22, 2025
- Cobenfy package inserts, accessed April 22, 2025
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Note: All information in “Nikki’s Story and Mom’s Story” are based on detail journals covering seven years of Nikki’s life on prescription drugs.
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