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Increase Your Awareness With Basic Facts About Caplyta (Lumateperone)
BY NIKKI AND ANNE HEART ♥ April 15, 2025
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The following highlights the basic facts. More information can be obtained through the sites listed below as well as many other informational sites regarding ingredients in medications and supplements. Information facts can change. Make sure you have all up-to-date information.
Basic facts about Caplyta (Lumateperone) include:
- Lumateperone is in a class of medications called atypical antipsychotics.
- Caplyta is indicated for the treatment of Schizophrenia in adults and Depressive episodes associated with bipolar I or II disorder (bipolar depression) in adults, as monotherapy and as adjunctive therapy with lithium or valproate.
Brand names for Lumateperone
- Caplyta®
Caplyta is FDA approved:
- FDA approval on December 20, 2019 for Schizophrenia in adults
- FDA approval on December 20, 2021, Treatment of Bipolar Depression in Adults
Important Safety Information
Medicines like CAPLYTA can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). CAPLYTA is not approved for treating people with dementia-related psychosis.
CAPLYTA and antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Patients and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when CAPLYTA or an antidepressant medicine is started or when the dose is changed. Report any change in these symptoms to your healthcare provider immediately.
Do not take CAPLYTA if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (e.g., rash, itching, hives, swelling of the tongue, lip, face, or throat).
Side effects that can be caused by Caplyta (Lumateperone)
- extreme tiredness or fatigue
- weight gain
- nausea
- dry mouth
- dizziness
Some side effects of Caplyta (Lumateperone) can be serious. If you experience any of the following symptoms, call your doctor immediately.
- rash, hives, or itching
- problems with coordination or increased falls
- unusual movements of your face or body that you cannot control
- sore throat, fever, chills, or other signs of infection
- fever; stiff muscles; sweating; confusion; or fast, pounding, or irregular heartbeat
- tightening of neck muscles or throat; or difficulty breathing or swallowing
- seizures
- stroke
- low white blood cell count
- problems with your metabolism
Special dietary concerns:
- Do not drink grapefruit juice or eat grapefruit while taking this medication.
Important Warning
Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as lumateperone have an increased chance of death during treatment. Older adults with dementia may also have a greater chance of having a stroke or mini-stroke during treatment.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body’s response to lumateperone.
Sourced used.
- Medlineplus.gov, Lumateperone, accessed April 11, 2025
- Caplyta, accessed April 11, 2025
- Drugs.com, Caplyta, accessed April 11, 2025
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Note: All information in “Nikki’s Story and Mom’s Story” are based on detail journals covering seven years of Nikki’s life on prescription drugs.
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